Influence in vitro on NK and K cell activities by cimetidine and indomethacin with and without simultaneous exposure to interferon |
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Authors: | Per Flodgren Hans Olov Sjögren |
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Institution: | (1) Department of Oncology, Lund Hospital, 22185 Lund, Sweden;(2) Department of Tumour Immunology, The Wallenberg Laboratory, University of Lund, 22007 Lund, Sweden |
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Abstract: | Summary The histamine-2 receptor antagonist cimetidine (10–5 M) and the prostaglandin synthesis inhibitor indomethacin (10–8 M) augmented natural killer cell activity in the majority of healthy controls and patients with advanced melanoma and in a lower frequency of patients with colorectal carcinoma. Antibody-dependent cellular cytotoxicity was increased in most melanoma patients but in a lower proportion of patients with colorectal cancer. Compared with the effect of interferon the augmentation of NK- and K-cell activities was small in most patients. Cimetidine was also demonstrated to bring about a further increase in the interferon-induced NK activation of peripheral blood mononuclear cells from a majority of healthy donors and patients with melanoma. Furthermore, cimetidine augmented the interferon-induced K-cell activation of peripheral blood mononuclear cells from most patients with melanoma and colorectal cancer. |
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