Primary and secondary autologous mixed-lymphocyte interactions in mice occur via antigens encoded by genes in the I region of the major histocompatibility complex |
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Authors: | M H Bocchieri J A Wolos J B Smith |
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Institution: | Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 USA |
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Abstract: | The antigens stimulating the autologous mixed-lymphocyte reactions (AMLR) were studied in experiments employing specific blocking antisera and through panels of secondary stimulating cells differing in the MHC. Antisera directed to the entire I region, I-A, I-EC, or A?Eα were all effective in blocking the primary AMLR. A principal role for those determinants encoded in I-A was indicated by secondary stimulation experiments. In secondary cultures, I-EC encoded determinants generated weaker responses in the absence of I-A homology. |
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Keywords: | To whom reprint requests and correspondence should be addressed Current address: Thomas Jefferson University Medical College 1015 Walnut Street Room 613 Philadelphia Pa 19107 |
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