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A vestige of a prebiotic bonding machine is functioning within the contemporary ribosome
Authors:Krupkin Miri  Matzov Donna  Tang Hua  Metz Markus  Kalaora Rinat  Belousoff Matthew J  Zimmerman Ella  Bashan Anat  Yonath Ada
Affiliation:Weizmann Institute of Science, Rehovot 76100, Israel.
Abstract:
Based on the presumed capability of a prebiotic pocket-like entity to accommodate substrates whose stereochemistry enables the creation of chemical bonds, it is suggested that a universal symmetrical region identified within all contemporary ribosomes originated from an entity that we term the 'proto-ribosome'. This 'proto-ribosome' could have evolved from an earlier machine that was capable of performing essential tasks in the RNA world, called here the 'pre-proto-ribosome', which was adapted for producing proteins.
Keywords:proto-ribosome   ribosomal symmetrical region   peptide bond formation   RNA world
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