Ethnic differences in cytokine gene polymorphisms: potential implications for cancer development |
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Authors: | Jovanny Zabaleta Barbara G Schneider Kelli Ryckman Pleasant F Hooper M Constanza Camargo M Blanca Piazuelo Rosa A Sierra Elizabeth T H Fontham Pelayo Correa Scott M Williams Augusto C Ochoa |
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Institution: | (1) Stanley S. Scott Cancer Center, LSUHSC, New Orleans, LA, USA;(2) Division of Gastroenterology, Vanderbilt University, Nashville, TN, USA;(3) Center for Human Genetic Research, Vanderbilt University School of Medicine, Nashville, TN, USA;(4) Biochemical Genetics Laboratory, Louisiana Office of Public Health, New Orleans, LA, USA;(5) School of Public Health, LSUHSC, New Orleans, LA, USA;(6) 533 Bolivar St, CSRB 455, New Orleans, LA 70112, USA;(7) Present address: Therapeutic Monitoring Services, L.L.C, New Orleans, LA, USA |
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Abstract: | Differences in incidence and outcome of cancer among ethnic groups may be explained by biological and/or socio-economic factors.
Genetic variations that affect chronic inflammation, a potentially important risk factor for carcinogenesis, may differ across
ethnic groups. Such differences may help explain cancer disparities among these groups. Single nucleotide polymorphisms (SNPs)
within cytokine genes can affect cytokine levels and the degree of inflammation. Associations between cancer and some cytokine
SNPs have been suggested. However, these have not been consistently replicated among populations, suggesting that SNP function
may differ according to ethnicity, or that SNPs alone do not completely account for regulation of inflammation. We examined
seven polymorphisms in African-American (n = 294) and Caucasian (n = 299) newborns in Louisiana: IL1B-511C > T, IL1B-31T > C, IL1B + 3954C > T, IL1RN*2, IL10-1082G > A, IL10-592C > A, and TNF-308G > A. African-American newborns had significantly higher frequencies of IL1B-511T, IL1B-31C, IL10-1082A and IL10-592A alleles and complete linkage equilibrium between IL1B + 3954 and IL1B-31. In contrast, IL1B + 3954T, IL1RN*2, and TNF-308A were more frequent in Caucasian newborns and exhibited strong linkage disequilibrium between IL1B + 3954 and IL1B-31. All allelic frequencies were significantly different between groups. We hypothesize that these dissimilarities may contribute
to differences in the inflammatory response and cancer incidence and mortality between African-Americans and Caucasians in
Louisiana. |
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Keywords: | Inflammation Single nucleotide polymorphisms Cytokines Cancer |
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