首页 | 本学科首页   官方微博 | 高级检索  
     


Deciphering the functional role of endothelial junctions by using in vivo models
Authors:Nyqvist Daniel  Giampietro Costanza  Dejana Elisabetta
Affiliation:IFOM, FIRC Institute of Molecular Oncology, Via Adamello 16, 20139 Milan, Italy.
Abstract:
Endothelial cell-to-cell junctions are vital for the formation and integrity of blood vessels. The main adhesive junctional complexes in endothelial cells, adherens junctions and tight junctions, are formed by transmembrane adhesive proteins that are linked to intracellular signalling partners and cytoskeletal-binding proteins. Gene inactivation and blocking antibodies in mouse models have revealed some of the functions of the individual junctional components in vivo, and are increasing our understanding of the functional role of endothelial cell junctions in angiogenesis and vascular homeostasis. Adherens-junction organization is required for correct vascular morphogenesis during embryo development. By contrast, the data available suggest that tight-junction proteins are not essential for vascular development but are necessary for endothelial barrier function.
Keywords:adherens junctions   endothelial cells   tight junctions   VE-cadherin
本文献已被 PubMed 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号