Flavans and other chemical constituents of Crinum biflorum (Amaryllidaceae) |
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| Institution: | 1. School of Pharmaceutical Science and Technology, Health Sciences Platform, Tianjin University, Tianjin, 300072, China;2. National Herbarium of Georgia, Ilia State University, Tbilisi, Georgia;3. Institute of Botany, Armenian National Academy of Sciences, Yerevan, Armenia;4. New York Botanical Garden, Bronx, NY, USA;1. Institute of Biology, University of Graz, Universitaetsplatz 2, 8010, Graz, Austria;2. Bulgarian Academy of Sciences, Institute of Biodiversity and Ecosystem Research, Department of Animal Diversity and Resources, 2 Gagarin Street, 1113, Sofia, Bulgaria;3. Research Unit of Osteology and Analytical Mass Spectrometry, Medical University, University Children''s Hospital, Auenbruggerplatz 30, 8036, Graz, Austria |
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| Abstract: | The ethyl acetate extract from the whole plant of Crinum biflorum Rottb. Showed a moderate activity against Enterococcus faecalis. Its phytochemical investigation led to the isolation of a new flavan-3-ol derivative namely (2R,3R)-3-hydroxy-7-methoxy-3′,4′-methylenedioxyflavan, together with (2S)-7-hydroxy-3′,4′-methylenedioxyflavan, (2R,3R)-7-methoxy-flavan-3-ol, (2S)-7-hydroxy-3′,4′-dimethoxyflavan, 3′,7-dihydroxy-4′-methoxyflavan, 4′,7-dimethoxy-3′-hydroxyflavan, farrerol, β-sitosterol, β-sitosterol-3-O-β-D-glucopyranoside, oleanolic acid, kaempferol, pancratistatin, lupeol, aurantiamide acetate, Narciprimine and 2,3-dihydroxypropyl palmitate. Their structures were elucidated mainly by extensive spectroscopic analysis and comparison with published data. The absolute configuration of the new metabolite was determined by electronic circular dichroism (ECD) analysis and comparison of optical rotation. Some of the isolated compounds were tested for their antimicrobial activity but no inhibition was observed. |
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| Keywords: | Amaryllidaceae Flavan-3-ol Chemotaxonomic significance Antimicrobial activity |
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