|
|||||
|
|
Sporadic cases in Duchenne muscular dystrophy |
|
| Authors: | Antonella Russo Guido Barbuiani Maria Luisa Mostacciuolo Falko H. Herrmann Aribert W. J. Spiegler Giuliana Galluzzi Gian Antonio Danieli |
| Affiliation: | (1) Insititute of Zoology, Via Borsari 46, I-44100 Ferrara, Italy;(2) Department of Biology, Via Trieste 75, I-35121 Padova, Italy;(3) Institut für Humangenetik, EMA Universität, Fleischmannstrasse 42, DDR-2200 Greifswald, German Democratic Republic;(4) Abteilung Medizinische Genetik, Medizinische Akademie, Klement-Gottwald-Strasse 34, DDR-508 Erfurt, German Democratic Republic;(5) Italian Muscular Dystrophy Association, Via San Crisogono 39, I-00153 Rome, Italy |
| Abstract: | Summary A new estimation of the proportion of sporadic cases in Duchenne muscular dystrophy was attempted by means of segregation analysis in a sample of 988 sibships collected on a world-wide scale by different authors. Maximum likelihood estimates of ascertainment probability (  ), segregation frequency (p), and frequency of sporadic cases (x) were calculated by Morton's equations under different hypotheses. The best fit was found for p=0.454±0.024 and x=0.235±0.034. The possibility that the proportion of sporadic cases might be lower than the expected 1/3 is suggested. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |