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Synthesis of glycosyl-triazole linked 1,2,4-oxadiazoles
Authors:dos Anjos Janaína V  Sinou Denis  de Melo Sebastiao J  Srivastava Rajendra M
Affiliation:Laboratoire de Synthèse Asymétrique, UMR 5246-ICBMS, CPE Lyon, Université de Lyon, 43 Boulevard du 11 Novembre 1918, F-69622 Villeurbanne, France.
Abstract:The synthesis of four different types of oxadiazoles containing a terminal acetylenic group is described. Reaction of these oxadiazoles with various azidoglycosides via a copper-catalyzed [3+2] cycloaddition ('click chemistry') afforded the corresponding glycosyl-triazole linked 1,2,4-oxadiazoles in good yields.
Keywords:Glycosyl azide   1,2,4-Oxadiazole   [3+2] Cycloaddition   Copper catalyst
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