Inducible, error-free DNA repair in tsl recA mutants of E. coli |
| |
Authors: | David W Mount Candace K Kosel and Anita Walker |
| |
Institution: | (1) Department of Microbiology, College of Medicine, University of Arizona, 85724 Tucson, Arizona, USA |
| |
Abstract: | Summary Host cell reactivation and UV reactivation and mutagenesis of UV-irradiated phage were measured in tsl recA
+ and tsl recA host mutants. Host cell reactivation was slightly more efficient in the tsl recA strain compared to the tsl
+
recA strain. Phage was UV-reactivated in the tsl recA strain with about one-half the efficiency of that in the wild type strain, but there was no corresponding mutagenesis of phage. UV-reactivation was also slightly lower and mutagenesis several-fold lower than normal in the tsl recA
+ strain. To account for these observations, we propose that there is an inducible, error-free pathway of DNA repair in E. coli that competes with error-prone repair for repair of phage lesions. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|