9-Deoxopodophyllotoxin derivatives as anti-cancer agents. |
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Authors: | D Subrahmanyam B Renuka G S Kumar V Vandana D S Deevi |
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Affiliation: | Natural Products division, Dr. Reddy's Research Foundation, Hyderabad, India. |
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Abstract: | Several 9-deoxo-9-substituted podophyllotoxin derivatives were synthesised starting from naturally occuring podophyllotoxin and their anti-cancer activity was evaluated against in vitro human cancer cell line assay. It was observed that these compounds do possess good anti-cancer activity particularly against ovarian, renal and lung cancer cell lines. |
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