Rapid repression of quiescence-specific gene expression by epidermal growth factor, insulin, and pp60v-src. |
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| Authors: | P A Bedard Y Yannoni D L Simmons and R L Erikson |
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| Institution: | Department of Cellular and Developmental Biology, Harvard University, Cambridge, Massachusetts 02138. |
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| Abstract: | We isolated a cDNA for p20K, a secreted protein preferentially synthesized in nonproliferating cells. p20K mRNA and protein levels declined rapidly following treatment with various mitogens. DNA sequence analysis of the p20K cDNA predicted a novel protein distantly related to alpha 2 mu-globulin and plasma retinol-binding protein. |
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