Adenosine deaminase normalizes cyclic AMP responses of hypothyroid rat fat cells to forskolin, but not beta-adrenergic agonists |
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Authors: | C C Malbon M P Graziano |
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Institution: | Department of Pharmacological Sciences, Health Sciences Center, The State University of New York at Stony Brook, Stony Brook, NY 11794, USA |
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Abstract: | Lipolysis and cyclic AMP accumulation in response to beta-adrenergic agonists or forskolin are severely impaired in fat cells from the hypothyroid rat. Incubating hypothyroid rat fat cells with adenosine deaminase normalizes the cyclic AMP response to forskolin, but not to beta-adrenergic agonists. Increased sensitivity to adenosine action in the hypothyroid state appears to be the basis for the impaired cyclic AMP response to forskolin, but does not appear to be the underlying defect responsible for the impaired response to beta-adrenergic agonists. |
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Keywords: | Hypothyroidism Cyclic AMP Forskolin β-Adrenergic agonist Adenosine deaminase |
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