Two common nonsynonymous paraoxonase 1 (<Emphasis Type="Italic">PON1</Emphasis>) gene polymorphisms and brain astrocytoma and meningioma期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Two common nonsynonymous paraoxonase 1 (PON1) gene polymorphisms and brain astrocytoma and meningioma

Authors:	Carmen Martínez José A Molina Hortensia Alonso-Navarro Félix J Jiménez-Jiménez José AG Agúndez Elena García-Martín

Affiliation:	1.Department of Pharmacology & Psychiatry, Medical School,University of Extremadura,Badajoz,Spain;2.Service of Neurology,Hospital Doce de Octubre,Madrid,Spain;3.Department of Medicine-Neurology, Hospital "Príncipe de Asturias", Universidad de Alcalá,Alcalá de Henares,Madrid,Spain;4.Section of Neurology, Hospital "La Mancha-Centro",Alcázar de San Juan,Ciudad Real,Spain;5.Department of Biochemistry and Molecular Biology and Genetics,University of Extremadura,Badajoz,Spain

Abstract:	Background Human serum paraoxonase 1 (PON1) plays a major role in the metabolism of several organophosphorus compounds. The enzyme is encoded by the polymorphic gene PON1, located on chromosome 7q21.3. Aiming to identify genetic variations related to the risk of developing brain tumors, we investigated the putative association between common nonsynonymous PON1 polymorphisms and the risk of developing astrocytoma and meningioma.

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