ENZYMATIC REGULATION OF ADENOSINE 3',5'-MONOPHOSPHATE (CYCLIC AMP) IN THE FREEZING EPILEPTOGENIC LESION OF RAT BRAIN AND IN HOMOLOGOUS CONTRALATERAL CORTEX |
| |
| Authors: | J. E. Walker E. Lewin J. R. Sheppard R. Cromwell |
| |
| Affiliation: | Division of Neurology, Veterans Administration Hospital and University of Colorado Medical Center, Denver, CO 80220, U.S.A. |
| |
| Abstract: | Freezing epileptogenic lesions were made unilaterally in rat cerebral cortex. Such lesions were associated with an increase in adenyl cyclase activity and a decrease in the membrane-associated phosphodiesterase activity, with a concomitant increase in the level of cyclic AMP. Similar, though less striking, changes occurred in homologous contralateral cortex (‘mirror focus’). The effects of cyclic AMP on brain membrane systems are discussed, with the suggestion that this substance may play an important role in the genesis of focal seizures. |
| |
| Keywords: | |
|
|
