| 外体和病毒感染 |
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| 引用本文： | 张晓阳,董春艳,段铭.外体和病毒感染[J].生物技术通讯,2014(4):560-563. |
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| 作者姓名： | 张晓阳 董春艳 段铭 |
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| 作者单位： | 吉林大学人兽共患病研究所/人兽共患病研究教育部重点实验室动物医学学院,吉林长春130062 |
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| 基金项目： | 国家自然科学基金（31172337） |
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| 摘 要： | 外体(exosome)是源自细胞内体的小囊泡,可由多种哺乳动物细胞分泌释放,其组分包括蛋白质、脂质、mRNA和microRNA,是细胞间"通讯"交互的工具之一。我们以介绍外体的组成和生物发生为基础,综述了近年来其在病毒感染致病中的研究成果,以期为病毒感染致病机理的研究提供新的切入点。
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| 关 键 词： | 外体 病毒 感染 |
The Role of Exosomes in Viral Infection |
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| ZHANG Xiao-Yang,DONG Chun-Yan,DUAN Ming.The Role of Exosomes in Viral Infection[J].Letters in Biotechnology,2014(4):560-563. |
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| Authors: | ZHANG Xiao-Yang DONG Chun-Yan DUAN Ming |
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| Institution: | (Key Laboratory of Zoonosis, Ministry of Education/Institute of Zoonosis, College of Veterinary Medicine, Jilin University, Changchun 130062, China) |
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| Abstract: | The exosome, as a nano vesicle that buds from the endosomal compartment, is produced and re-leased by all kinds of mammalian cells. This vesicle contains a variety of proteins, lipids, mRNA and microRNA. These components are specific to the origin of the exosomes and contribute to cell-cell communications. Most of the exosomes involved in viral infection can either spread or limit an infection based on the type of virus and its target cells. In this review, we introduced the exosome, its origin and function, then we discussed its roles in vi-ral infection which is involved in the fate of the infection. |
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| Keywords: | exosome virus infection |
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