肿瘤标志物CEA、CA199对结直肠癌TNM分期的预判价值

目的:探讨肿瘤标志物CEA、CA199浓度变化在结直肠癌TNM分期中的预判价值。方法:回顾我院2010年1月~2013年10月收治的经手术治疗的结、直肠癌患者(共96例)的有关资料,分析其术前CEA、CA199浓度水平与术后病理确定TNM分期结果的相互关系,进行相应的统计学检测。结果:结直肠癌Ⅰ~Ⅳ期CEA浓度依次为4.28±1.78、6.92±2.01、23.99±6.49和362.64±158.80 ng/mL,CA199浓度依次为12.58±2.98、13.37±2.62、36.84±10.33和238.71±103.69 U/mL,肿瘤标志物CEA、CA199的浓度随TNM分期升级而增高,通过Kruskal-Wallis秩检验分析及Spearman秩相关分析,表明CEA、CA199的血清浓度与TNM分期明显相关(P0.01)。结论:CEA、CA199血清浓度与TNM分期呈正相关,而年龄与CEA、CA199在各期中的浓度无明显相关性。因此,应用CEA、CA199的血清学测定在一定程度上具有预判结直肠癌TNM分期的价值。

Predicting Values of Tumer Markers CEA and CA199 for the TNM Staging in Colorectal Tumor Patients

Objective： To estimate the predicting value of the concentration alternation of tumor markers CEA and CA199 in colorectal cancer TNM staging. Methods： Total 96 colorectal cancer patients were collected from January 2010 to October 2013 of our hospital inpatients, whose CEA, CA199 concentration were measured before surgery and the TNM staging were concerned after surgery. The relation between the concentration alternation and TNM staging was analyzed statistically. Results： Tumor marker concentration in colorectal cancer TNM staging from Ⅰ to Ⅳ was 4.28±1.78, 6.92±2.01, 23.99±6.49 and 362.64±158.80 ng/mL（for CEA respectively）, and 12.58± 2.98, 13.37±2.62, 36.84±10.33 and 238.71±103.69 U/mL（for CA199 respectively）. Both CEA and CA199 concentration was increased along with the upgrading of TNM staging. By using the Kruskal-Wallis test and Spearman analysis, the data showed the correlation of the tumor markers＇ concentration with the colorectal cancer TNM staging （P〈0.01）. Conclusion： It was the CEA/CA199 serum concentration, not the age, showed the positive correlation with TNM staging, meanwhile, in different age and sex group, the CEA/CA199 concentration displayed no difference. Thus, to some extent, the serum concentration of CEA/CA199 could be used to anticipate the TNM staging of colorectal cancer.