Heparin inhibits IP3-induced Ca2+ release in permeabilized pancreatic beta-cells |
| |
| Authors: | T Nilsson J Zwiller A L Boynton P O Berggren |
| |
| Affiliation: | Department of Medical Cell Biology, University of Uppsala, Sweden. |
| |
| Abstract: | Heparin was found to inhibit the Ca2+ release induced by inositol 1,4,5-trisphosphate (IP3) in permeabilized pancreatic beta-cells obtained from obese hyperglycemic mice. The effect of heparin was dose-dependent and not due to inhibition of Ca2+ uptake into the IP3-sensitive pool. The effect appeared specific for heparin and was not reproduced by other polysaccharides such as chondroitin sulfates. Heparin might consequently be a useful tool when investigating the molecular mechanism whereby IP3 mobilizes Ca2+. |
| |
| Keywords: | |
|
|
