Computer simulation of calcium-induced myotonia |
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| Authors: | A. Da Ronch H. Radu V. Caldesi-Valeri |
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| Affiliation: | (1) Laboratorio di Dinamica dei Sistemi ed Elettronica Biomedica, CNR, Padua, Italy;(2) Spitalul de Patologie Neuro-musculara, Vilcele, Roumania;(3) Istituto di Fisiologia Umana dell'Università, Padua, Italy |
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| Abstract: | Summary In an extensive research project on myotonia, the ionic mechanisms which are at the basis of the phenomenon of calcium-induced myotonia have been taken into consideration. A mathematical model of a muscle fibre was constructed to demonstrate the possibility that anomalous values of the membrane permeability to Calcium ions have an active part in the genesis of myotonia. This work was in great part supported by Grant of Muscular Dystrophy Assoc. Inc. and by CNR, Rome. |
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| Keywords: | Sarcolemma Action potential Ionic membrane conductances Ionic equilibrium potentials Calcium Pump Myotonic behaviour |
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