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High-resolution crystal structure of MltE, an outer membrane-anchored endolytic peptidoglycan lytic transglycosylase from Escherichia coli
Authors:Artola-Recolons Cecilia  Carrasco-López César  Llarrull Leticia I  Kumarasiri Malika  Lastochkin Elena  Martínez de Ilarduya Iñaki  Meindl Kathrin  Usón Isabel  Mobashery Shahriar  Hermoso Juan A
Affiliation:Department of Crystallography and Structural Biology, Instituto de Qui?mica-Fi?sica "Rocasolano", CSIC, Serrano 119, 28006 Madrid, Spain.
Abstract:
The crystal structure of the first endolytic peptidoglycan lytic transglycosylase MltE from Escherichia coli is reported here. The degradative activity of this enzyme initiates the process of cell wall recycling, which is an integral event in the existence of bacteria. The structure sheds light on how MltE recognizes its substrate, the cell wall peptidoglycan. It also explains the ability of this endolytic enzyme to cleave in the middle of the peptidoglycan chains. Furthermore, the structure reveals how the enzyme is sequestered on the inner leaflet of the outer membrane.
Keywords:
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