Functional identification of optimized RNAi triggers using a massively parallel sensor assay期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Functional identification of optimized RNAi triggers using a massively parallel sensor assay

Authors:	Fellmann Christof Zuber Johannes McJunkin Katherine Chang Kenneth Malone Colin D Dickins Ross A Xu Qikai Hengartner Michael O Elledge Stephen J Hannon Gregory J Lowe Scott W

Affiliation:	Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Abstract:	Download : Download high-res image (126KB) Download : Download full-size image Highlights? The Sensor assay reliably identifies potent single-copy shRNAs ? Potent shRNAs are rare and generally not predicted by existing algorithms ? Analyses of ～20,000 shRNAs reveal insights into shRNA biogenesis and function ? Sensor-based rules provide a criteria framework for rational shRNA design

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