Effects of chlorogenic acid and its metabolites on spontaneous locomotor activity in mice |
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| Authors: | Ohnishi Ryoko Ito Hideyuki Iguchi Ayumu Shinomiya Kazuaki Kamei Chiaki Hatano Tsutomu Yoshida Takashi |
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| Institution: | Department of Pharmacognosy, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Japan. |
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| Abstract: | Chlorogenic acid possessed a weak caffeine-like psychostimulant property when assessed for its effect on spontaneous locomotor activity in mice. In the evaluation of the effects for the major metabolites of chlorogenic acid which were detected upon incubation with rat feces and/or excreted in urine after oral administration to rats, caffeic and m-coumaric acids were found to be the principal active metabolites, while the others contributed little to this caffeine-like psychostimulant activity. |
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