A new member of a secretory protein gene family in the dipteranChironomus tentans has a variant repeat structure |
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| Authors: | Joakim Galli Urban Lendahl Gabrielle Paulsson Christer Ericsson Tomas Bergman Mats Carlquist Lars Wieslander |
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| Institution: | (1) Department of Molecular Genetics, Medical Nobel Institute, Karolinska Institutet, Box 60400, S-104 01 Stockholm, Sweden;(2) Department of Physiological Chemistry, Karolinska Institutet, Box 60400, S-104 01 Stockholm, Sweden;(3) Department of Biochemistry II, Karolinska Institutet, Box 60400, S-104 01 Stockholm, Sweden;(4) Present address: Molecular Biology and Virology Laboratory, The Salk Institute, PO Box 85800, 92138 San Diego, California, USA;(5) Present address: Karo Bio, Box 4032, 141 04 Huddinge, Sweden |
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| Abstract: | Summary We describe the structure of a gene expressed in the salivary gland cells of the dipteranChironomus tentans and show that it encodes 1 of the approximately 15 secretory proteins exported by the gland cells. This sp115,140 gene consists of approximately 65 copies of a 42-bp sequence in a central uninterrupted core block, surrounded by short nonrepetitive regions. The repeats within the gene are highly similar to each other, but divergent repeats are present in a pattern which suggests that the repeat structure has been remodeled during evolution. The 42-bp repeat in the gene is a simple variant of the more complex repeat unit present in the Balbiani ring genes, encoding four of the other secretory proteins. The structure of the sp115,140 gene suggests that related repeat structures have evolved from a common origin and resulted in the set of genes whose secretory proteins interact in the assembly of the secreted protein fibers. |
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| Keywords: | Gene family Repetitive sequences Structural proteins Balbiani ring genes |
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