Synthesis and structure-activity relationships of 1,5-diazaanthraquinones as antitumour compounds |
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Authors: | Avendaño Carmen Pérez José María Blanco Maria del Mar de la Fuente Jesús Angel Manzanaro Sonia Vicent María Jesús Martín María Jesús Salvador-Tormo Nélida Menéndez J Carlos |
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Institution: | Departamento de Química Orgánica y Farmacéutica, Facultad de Farmacia, Universidad Complutense, 28040 Madrid, Spain. |
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Abstract: | 1,5-Diazaanthraquinone derivatives were synthesized employing single and double hetero Diels-Alder strategies. Their in vitro antitumour activity was assayed using three cell lines. Some of these compounds, specially those bearing methyl or ethyl groups at the C-3,7 positions or chloro at C-4 and methyl at C-7, showed IC(50) values in the 10(-8)M range for human lung carcinoma and human melanoma, which makes them attractive candidates for further development as anticancer agents. |
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