Human metallothionein genes: structure of the functional locus at 16q13 |
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| Authors: | A K West R Stallings C E Hildebrand R Chiu M Karin R I Richards |
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| Institution: | Department of Biochemistry, University of Tasmania, Australia. |
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| Abstract: | The functional human metallothionein (MT) genes are located on chromosome 16q13. We have physically mapped the functional human MT locus by isolation and restriction digest mapping of cloned DNA. The mapped region contains all sequences on chromosome 16 that hybridize to metallothionein gene probes and comprises 14 tightly linked MT genes, 6 of which have not been previously described. This analysis defines the genetic limits of metallothionein functional diversity in the human genome. |
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