High content image analysis for human H4 neuroglioma cells exposed to CuO nanoparticles |
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| Authors: | Fuhai Li Xiaobo Zhou Jinmin Zhu Jinwen Ma Xudong Huang Stephen TC Wong |
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| Institution: | (1) The Center for Biomedical Informatics, The Methodist Hospital Research Institute, Weill Cornell Medical College, Houston, TX 77030, USA;(2) Department of Information Science, School of Mathematical Sciences, and LMAM, Peking University, Beijing, 100871, China;(3) Research Division, Department of Radiology, The Methodist Hospital, Weill Cornell Medical College, Houston, TX 77030, USA;(4) Functional and Molecular Imaging Center, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA;(5) Neurochemistry Laboratory, Department of Psychiatry and Genetics and Aging Research Unit, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA |
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| Abstract: | Background High content screening (HCS)-based image analysis is becoming an important and widely used research tool. Capitalizing this
technology, ample cellular information can be extracted from the high content cellular images. In this study, an automated,
reliable and quantitative cellular image analysis system developed in house has been employed to quantify the toxic responses
of human H4 neuroglioma cells exposed to metal oxide nanoparticles. This system has been proved to be an essential tool in
our study. |
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