Insertions and the emergence of novel protein structure: a structure-based phylogenetic study of insertions |
| |
Authors: | Haiyan Jiang Christian Blouin |
| |
Institution: | (1) Faculty of Computer Science, Dalhousie University, Halifax, Nova Scotia, B3H 1W5, Canada;(2) Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, B3H 1X5, Canada |
| |
Abstract: | Background In protein evolution, the mechanism of the emergence of novel protein domain is still an open question. The incremental growth
of protein variable regions, which was produced by stochastic insertions, has the potential to generate large and complex
sub-structures. In this study, a deterministic methodology is proposed to reconstruct phylogenies from protein structures,
and to infer insertion events in protein evolution. The analysis was performed on a broad range of SCOP domain families. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|