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Evaluation of endo- and exo-aryl-substitutions and central scaffold modifications on diphenyl substituted alkanes as 5-lipoxygenase activating protein inhibitors |
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| Authors: | Chu Lin Armstrong Helen M Chang Linda L Cheng Amy F Colwell Lawrence Cui Jisong Evans Jilly Galka Amy Goulet Mark T Hayes Nancy Lo Jane Menke John Ok Hyun O Ondeyka Debra L Patel Minal Quaker Grace M Sings Heather Witkin Stephanie L Zhao Annie Ujjainwalla Feroze |
| Institution: | Discovery and Preclinical Sciences, Merck Research Laboratories, Rahway, NJ 07065, USA. lin_chu@merck.com |
| Abstract: | A search for a suitable replacement for the central norbornyl scaffold presented in the recently disclosed novel FLAP inhibitors is herein described, as well as the SAR study performed on the endo and exo-aryl groups. |
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