| BMP/Smad信号通路与哺乳动物卵泡发生 |
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| 引用本文： | 王伟,王少兵,徐银学.BMP/Smad信号通路与哺乳动物卵泡发生[J].遗传,2009,31(3):245-254. |
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| 作者姓名： | 王伟 王少兵 徐银学 |
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| 作者单位： | 南京农业大学动物科学技术学院, 南京 210095 |
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| 基金项目： | 国家高技术研究发展计划(863计划) |
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| 摘 要： | BMPs属于TGF-b超家族成员, 在调节哺乳动物的生长、细胞增殖和分化等方面有很广泛的生物学功能。越来越多的证据显示, BMPs在雌性哺乳动物生殖, 尤其在卵泡发生过程中发挥重要作用。Smads蛋白是BMP家族细胞内信号转导分子, 可将BMPs胞外信号从细胞膜传递入细胞核。文章对BMPs、BMP/Smad信号通路和BMP如何被调节进行概述, 并重点对BMP/Smad信号通路在卵泡发生过程中所起的调控作用进行综述。
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| 关 键 词： | BMPs Smads 卵泡发生 信号通路 |
| 收稿时间： | 2008-07-14 |
| 修稿时间： | 2008-09-02 |
Signal transduction of BMP/Smad and its relationship with mammalian folliculogenesis |
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| WANG Wei,WANG Shao-Bing,XU Yin-Xue.Signal transduction of BMP/Smad and its relationship with mammalian folliculogenesis[J].Hereditas,2009,31(3):245-254. |
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| Authors: | WANG Wei WANG Shao-Bing XU Yin-Xue |
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| Institution: | College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China |
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| Abstract: | BMPs belong to the transforming growth factor-b superfamily. BMPs have been proved to have extensive bio-logical functions in mammals, including growth regulation, cell proliferation and differentiation. More and more evidence has shown that BMPs play a key role in fertility, especially in folliculogenesis in female mammals. Smad proteins are intra-cellular signaling transduction molecules of BMP family, which can transduce the BMP signal from the cell membrane to the nucleus. In this review, BMPs, BMP/Smad-related signal transduction and the regulation of BMP activity were summa-rized, and the regulatory roles of BMP/Smad signal transduction pathway in folliculogenesis were discussed. |
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| Keywords: | BMPs Smads |
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