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Mycobacterium leprae binds to a major human peripheral nerve glycoprotein myelin P zero (P0) |
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| Authors: | Suneetha Lavanya M Singh Surya S Vani Meher Vardhini Deena Scollard David Archelos Juan J Srinivasulu M Suneetha Sujai |
| Institution: | (1) LEPRA India-Blue Peter Research Centre, Hyderabad, India;(2) Department of Biochemistry, Osmania University, Hyderabad, India;(3) National Hansen's Disease Centre, Baton Rouge, Louisiana, USA;(4) Department of Neurology, University of Graz, Austria;(5) MNJ Cancer Hospital, Hyderabad, India |
| Abstract: | We have previously shown that a major phosphorylated 25-kDa glycoprotein of the human peripheral nerve binds to Mycobacterium leprae. In the present study, we confirm that the 25-kDa glycoprotein of the human peripheral nerve is myelin P zero (P0) by immunoprecipitation and Western blot experiments using monoclonal antibodies to myelin P0. Immunohistochemical studies on human nerve using these antibodies to myelin P0 exhibited a strong immunoreactivity to the myelin and Schwann cells. Myelin P0 is a peripheral nerve specific protein; therefore it could likely be one of the key target molecules for M. leprae binding/internalization or even contact-dependent demyelination. This finding of M. leprae binding to myelin P0 adds to the present understanding on neural predilection of M. leprae. |
| Keywords: | Human peripheral nerve protein phosphorylation Mycobacterium leprae Myelin P0 |
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