| ILK和VEGF165b在人肾癌组织中的表达及意义 |
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| 引用本文： | 蓝建华,唐贤富,郑兴明,徐小涵,王德林. ILK和VEGF165b在人肾癌组织中的表达及意义[J]. 生命科学研究, 2011, 15(3): 259-262 |
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| 作者姓名： | 蓝建华 唐贤富 郑兴明 徐小涵 王德林 |
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| 作者单位： | 1. 川北医学院附属广安市人民医院,中国四川广安,638000
2. 重庆医科大学附属第一医院,中国重庆,400016 |
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| 摘 要： | 探讨整合素连接激酶(ILK)和血管内皮生长因子165b(VEGF165b)在人肾癌组织中的表达及临床意义.利用免疫组织化学S-P法检测35例肾癌组织和25例正常肾组织中ILK和VEGF165b蛋白的表达,并与肾癌临床分期进行比较.35例肾癌组织中,ILK表达率为82.9%(29/35),VEGF165b表达率为17.1%(6/35);而25例正常肾组织中ILK表达率为28.0%(7/25),VEGF165b表达率为96.0%(24/25).肾癌中ILK的表达与VEGF165b的表达呈负相关(P<0.01);ILK与VEGF165b的表达均与肾癌的临床分期有关.ILK在肾癌组织中异常活性表达,VEGF165b在肾癌组织的表达明显降低,二者表达成负相关,与肾癌的发生、发展密切相关.
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| 关 键 词： | 肾肿瘤 整合素连接激酶 血管内皮生长因子165b(VEGF165b) 免疫组织化学 |
Expression and Significance of ILK and VEGF165b in Renal Cell Carcinoma |
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| LAN Jian-hua,TANG Xian-fu,ZHENG Xing-ming,XU Xiao-han,WANG De-lin. Expression and Significance of ILK and VEGF165b in Renal Cell Carcinoma[J]. Life Science Research, 2011, 15(3): 259-262 |
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| Authors: | LAN Jian-hua TANG Xian-fu ZHENG Xing-ming XU Xiao-han WANG De-lin |
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| Affiliation: | LAN Jian-hua1,TANG Xian-fu1,ZHENG Xing-ming1,XU Xiao-han1,WANG De-lin2(1.North Sichuan Medical College,Guangan City People's Hospital,Guangan 638000,Sichuan,China,2.The First Affiliated Hospital,Chongqing Medical University,Chongqing 400016,China) |
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| Abstract: | Investigation of the expression and significance of integrin-linked kinase(ILK) and vascular en-dothelial growth factor 165b(VEGF165b) in human renal cell carcinoma(RCC).Immunohistochemistry was used to detect the expression of ILK and VEGF165b in 40 cases of RCC and 25 cases of renal tissue.The correlation between the expression in RCC and pathological stage was examined.In 35 cases of renal cell carcinoma,ILK expression rate was 82.9%(29/35) and VEGF165b expression rate was 17.1%(6/35);In 25 cases of norm... |
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| Keywords: | kidney neoplasms integrin-linked kinase vascular endothelial growth factor 165b(VEGF165b) immunohistochemistry |
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