Substitution of 2-Aminoadenine and 5-Methylcytosine for Adenine and Cytosine in Hybridization Probes Increases the Sensitivity of DNA Fingerprinting期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Substitution of 2-Aminoadenine and 5-Methylcytosine for Adenine and Cytosine in Hybridization Probes Increases the Sensitivity of DNA Fingerprinting

Authors:	M. I. Prosnyak S. I. Veselovskaya V. A. Myasnikov E. J. Efremova V. K. Potapov S. A. Limborska E. D. Sverdlov

Abstract:	An oligonucleotide (m⁵C-am²A-m⁵C)₅ containing 2′-amino-deoxyadenosine (am²A) and 5-methyldeoxycytidine (m⁵C) residues has been synthesized and compared with unsubstituted pentadecadeoxyribonucleotide (CAC)₅ as a hybridization probe for DNA fingerprinting. It was shown that considerably higher sensitivity can be achieved with the modified analog.

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