Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Structure-activity relationship of 5'-substituted fluoro-neplanocin a analogues as potent inhibitors of S-adenosylhomocysteine hydrolase

Authors:	Moon Hyung Ryong Lee Kang Man Lee Joo Hyun Lee Sang Kook Park Seung Bin Chun Moon Woo Jeong Lak Shin

Affiliation:	College of Pharmacy, Pusan National University, Pusan 609-735, Korea.

Abstract:	Four 5'-substituted fluoro-neplanocin A analogues la-d were designed and synthesized, and the inhibitory activity against SAH was in the following order: NH2 > SH > F, N3, indicating a hydrogen bonding donor is essential for inhibitory activity.

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