| 氧化修饰高密度脂蛋白的研究进展 |
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| 引用本文： | 傅强,刘秉文.氧化修饰高密度脂蛋白的研究进展[J].生物化学与生物物理进展,2000,27(3):261-265. |
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| 作者姓名： | 傅强 刘秉文 |
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| 作者单位： | 华西医科大学生物化学与分子生物学研究所,成都,610041 |
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| 基金项目： | 国家教育部博士学科点科研基金及纽约中华医学基金部分资助. |
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| 摘 要： | 血浆高密度脂蛋白(HDL)与低密度脂蛋白(LDL)一样可以在体内外发生氧化修饰，引起其理化性质发生一系列的改变，如多不饱和脂肪酸过氧化，卵磷脂水解，蛋白质发生聚合或分解等.活体内HDL可能在动脉壁巨噬细胞、内皮细胞及中性粒细胞、单核细胞的作用下发生氧化修饰.氧化修饰HDL可能通过清道夫受体途径代谢.氧化修饰HDL产生多种致动脉粥样硬化作用.维生素E、C的摄入可能有助于防止脂蛋白的氧化.
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| 关 键 词： | 高密度脂蛋白，氧化修饰，动脉粥样硬化，胆固醇逆向转运，抗氧化剂 |
| 收稿时间： | 1999/6/15 0:00:00 |
| 修稿时间： | : |
Progress of Oxidative High Density Lipoprotein Research |
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| FU Qiang and LIU Bing-Wen.Progress of Oxidative High Density Lipoprotein Research[J].Progress In Biochemistry and Biophysics,2000,27(3):261-265. |
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| Authors: | FU Qiang and LIU Bing-Wen |
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| Institution: | Institute of Biochemistry and Molecular Biology, West China University of Medical Sciences, Chengdu 610041, China;Institute of Biochemistry and Molecular Biology, West China University of Medical Sciences, Chengdu 610041, China |
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| Abstract: | Plasma high density lipoprotein(HDL) can be oxidized in vitro and in vivo as can low density lipoprotein(LDL), which causes many changes in HDL properties, such as peroxidation of polyunsaturated fatty acids, hydrolysis of phosphatidylcholine, apolipoprotein aggregation or degradation. HDL oxidative modification in vivo might be induced by arterial endothelial cells, macrophages and blood polymorphonuclears, monocytes. Ox-HDL might metabolize through scavenger receptors but not normal HDL receptors. Ox-HDL has many atherogenic roles. Vitamin E, C supplementation can inhibit HDL oxidation and may prevent the atherosclerosis. |
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| Keywords: | high density lipoprotein oxidatively modification atherosclerosis reverse cholesterol transport antioxidants |
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