Continuous-flow solid-phase synthesis of potential antigenic peptides of hepatitis B virus |
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| Authors: | F Rabanal I Haro F Reig J M García-Antón |
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| Institution: | Laboratory of Peptides, C.I.D., C.S.I.C., Barcelona, Spain. |
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| Abstract: | The synthesis of three hepatitis B surface antigens derived from S and pre-S proteins (adw S(140-147), Tyr148] adw S(139-148), and adw pre-S(120-145)) has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of different scavengers and trimethylsilyl bromide (TMSBr) in trifluoroacetic acid as deprotecting procedures is discussed. |
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