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Genome-wide Study of Atrial Fibrillation Identifies Seven Risk Loci and Highlights Biological Pathways and Regulatory Elements Involved in Cardiac Development
Authors:Jonas B. Nielsen  Lars G. Fritsche  Wei Zhou  Tanya M. Teslovich  Oddgeir L. Holmen  Stefan Gustafsson  Maiken E. Gabrielsen  Ellen M. Schmidt  Robin Beaumont  Brooke N. Wolford  Maoxuan Lin  Chad M. Brummett  Michael H. Preuss  Lena Refsgaard  Erwin P. Bottinger  Sarah E. Graham  Ida Surakka  Yunhan Chu  Cristen J. Willer
Affiliation:1. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, MI 48109, USA;2. Department of Human Genetics, University of Michigan, Ann Arbor, MI 48109, USA;3. HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger 7600, Norway;4. Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA;5. K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim 7491, Norway;6. Regeneron Genetics Center, Tarrytown, NY 10591, USA;7. Department of Cardiology, St. Olav’s University Hospital, Trondheim 7030, Norway;8. Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala 75237, Sweden;9. Royal Devon & Exeter NHS Foundation Trust and University of Exeter Barrack Road Exeter, Exeter EX2 5WD, UK;10. Department of Anesthesiology, University of Michigan, Ann Arbor, MI 48109, USA;11. Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;12. Genetics of Obesity and Related Metabolic Traits Program, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;13. Laboratory for Molecular Cardiology, Department of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen 2100, Denmark;14. Mindich Child Health Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA;15. Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger 7600, Norway;16. Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim 7491, Norway;17. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI 48109, USA;18. Department of Internal Medicine, Center for Arrhythmia Research, University of Michigan, Ann Arbor, MI 48109, USA;19. Fundacion Centro Nacional de Investigaciones Cardiovasculares, Madrid 28029, Spain;20. Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2200, Denmark;21. Department of Biomedicine, University of Copenhagen, Copenhagen 2200, Denmark;22. Department of Community Medicine, Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø 9019, Norway;23. Geisinger Health System, Danville, PA 17822, USA;24. Division of Cardiovascular Medicine, Department of Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA
Abstract:
Keywords:heart  fetal  atrial fibrillation  GWAS  pathway  genetic risk score  cardiomyopathy  TTN  DMRTA2  CDKN2C
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