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Small RNA profiling of Dengue virus-mosquito interactions implicates the PIWI RNA pathway in anti-viral defense |
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| Authors: | Ann M Hess Abhishek N Prasad Andrey Ptitsyn Gregory D Ebel Ken E Olson Catalin Barbacioru Cinna Monighetti Corey L Campbell |
| Affiliation: | (1) Department of Statistics, Colorado State University, 80523 Fort Collins, Colorado, USA;(2) Department of Pathology, University of New Mexico School of Medicine, 87131 Albuquerque, NM, USA;(3) Microbiology, Immunology, and Pathology Dept, Colorado State University, 80523 Fort Collins, Colorado, USA;(4) Arthropod-borne Infectious Diseases Laboratory, Colorado State University, 80523 Fort Collins, Colorado, USA;(5) Life Technologies, 94404 Foster City, CA, USA;(6) Department of Biochemistry and Molecular Biology, Colorado State University, 80523 Fort Collins, Colorado, USA |
| Abstract: | BackgroundSmall RNA (sRNA) regulatory pathways (SRRPs) are important to anti-viral defence in mosquitoes. To identify critical features of the virus infection process in Dengue serotype 2 (DENV2)-infected Ae. aegypti, we deep-sequenced small non-coding RNAs. Triplicate biological replicates were used so that rigorous statistical metrics could be applied. |
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