A Systematic Review Concerning the Relation between the Sympathetic Nervous System and Heart Failure with Preserved Left Ventricular Ejection Fraction |
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| Authors: | Willemien L. Verloop Martine M. A. Beeftink Bernadet T. Santema Michiel L. Bots Peter J. Blankestijn Maarten J. Cramer Pieter A. Doevendans Michiel Voskuil |
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| Affiliation: | 1Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands;2The Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, the Netherlands;3Department of Nephrology, University Medical Center Utrecht, Utrecht, the Netherlands;Loyola University Chicago, UNITED STATES |
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| Abstract: | BackgroundHeart failure with preserved left ventricular ejection fraction (HFPEF) affects about half of all patients diagnosed with heart failure. The pathophysiological aspect of this complex disease state has been extensively explored, yet it is still not fully understood. Since the sympathetic nervous system is related to the development of systolic HF, we hypothesized that an increased sympathetic nerve activation (SNA) is also related to the development of HFPEF. This review summarizes the available literature regarding the relation between HFPEF and SNA.ConclusionCurrent literature confirms a relation between increased SNA and HFPEF. However, current literature is not able to distinguish whether enhanced SNA results in HFPEF, or HFPEF results in enhanced SNA. The most likely setting is a vicious circle in which HFPEF and SNA sustain each other. |
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