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Synthesis and SAR of 2-(4-fluorophenyl)-3-pyrimidin-4-ylimidazo[1,2-a]pyridine derivatives as anticoccidial agents |
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| Authors: | Feng Dennis Fisher Michael Liang Gui-Bai Qian Xiaoxia Brown Chris Gurnett Anne Leavitt Penny Sue Liberator Paul A Mathew John Misura Andrew Samaras Samantha Tamas Tamas Schmatz Dennis M Wyvratt Matthew Biftu Tesfaye |
| Institution: | Merck Research Laboratories, Department of Medicinal Chemistry, Merck and Co., Inc., PO Box 2000, Rahway, NJ 07065, USA. dennis_feng@merck.com |
| Abstract: | Compounds 10a-10d and 10i are very potent inhibitors of Eimeria tenella cGMP-dependent protein kinase (0.081-0.32 nM) and are very efficacious antiparasitic agents in vivo when administered to chickens at 12.5-25 ppm levels in the feed. |
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