| Notch信号通路对神经干细胞增殖分化的作用 |
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| 引用本文： | 王珏,邓宇斌,万勇.Notch信号通路对神经干细胞增殖分化的作用[J].细胞生物学杂志,2014(5):708-712. |
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| 作者姓名： | 王珏 邓宇斌 万勇 |
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| 作者单位： | [1]中山大学附属第一医院,转化医学中心实验室,广州510080 [2]中山大学附属第一医院,脊柱外科,广州510080 |
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| 基金项目： | 国家自然科学基金（批准号：81171711）和广东省自然科学基金（批准号：S2013020012818）资助的课题 |
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| 摘 要： | 神经干细胞作为一种具有自我更新能力和多向分化潜能的细胞，它的增殖和分化受到多种源于自身或外在、邻近或远程细胞信号通路的调控，各种细胞因子及胞间通讯在神经干细胞的增殖和分化中发挥着重要的作用。近年来的多种研究表明，Notch信号通路正是这样一种可以通过相邻细胞的配体与受体相互作用，从而传递信号，进一步发挥其生物学功能的重要信号通路。该通路参与了神经干细胞维持自我形态及向多种具有不同功能的神经细胞分化的过程．对于研究神经干细胞的增殖和分化具有巨大的意义。该文将就当前Notch信号通路对神经干细胞增殖分化影响的相关研究进行简要综述。
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| 关 键 词： | Notch信号通路 神经干细胞 增殖 分化 |
The Effects of Notch Signaling Pathway on Neural Stem Cells Proliferation and Differentiation |
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| Wang Jue,Deng Yubin,Wan Yong.The Effects of Notch Signaling Pathway on Neural Stem Cells Proliferation and Differentiation[J].Chinese Journal of Cell Biology,2014(5):708-712. |
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| Authors: | Wang Jue Deng Yubin Wan Yong |
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| Institution: | 1Research Center of Translational Medicine, the First AffiliatedHospital, Sun Yat-sen University, Guangzhou 510080, China; 2Department of Spine Surgery, the First AffiliatedHospital, Sun Yat-sen University, Guangzhou 510080, China) |
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| Abstract: | Neural stem cells （NSCs） have the ability of self-renew and multiple differentiations. The proliferation and differentiation of NSCs can be regulated by internal or external, adjacent or far-off cell signaling pathways. Recently, researchers indicated that Notch signaling pathway probably can deliver cell signal though receptors and ligands of adjacent cells and then impact NSCs morphology and their neural differentiation. Recent researches on the effects of Notch signaling pathway on NSCs proliferation and differentiation were reviewed in this paper. |
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| Keywords: | notch signaling pathway neural stem cells proliferation differentiation |
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