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Genotype and haplotype analysis of the AZGP1 gene in cattle |
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| Authors: | Bao Zhang Yi Kun Guo Shengbin Li Liang Zhi Zhang Xian Yong Lan Shen Rong Hu Hong Chen |
| Affiliation: | 1. College of Animal Science and Technology, Northwest A&F University, Shaanxi Key Laboratory of Molecular Biology for Agriculture, No. 22 Xinong Road, Yangling, 712100, Shaanxi, People’s Republic of China 2. Key Laboratory of National Ministry of Health for Forensic Sciences, College of Medicine, Xi’an Jiaotong University, Xi’an, 710061, People’s Republic of China 3. Key Laboratory of Environment and Genes Related to Diseases, Xi’an Jiaotong University, Ministry of Education, Xi’an, Shannxi, People’s Republic of China |
| Abstract: | Zinc-a2-glycoprotien (AZGP1) involved in lipid metabolism and associated with adipose tissue atrophy in cachexia. And it also related to sperm motility and in turn fertilization. To ascertain whether there were mutations in the bovine AZGP1 gene, this study investigated variation of the AZGP1 gene through PCR-SSCP and sequencing. Four missense mutations were identified in 649 cattle from six independent populations. Haplotype frequencies and linkage disequilibrium (LD) coefficients of these SNPs in three Chinese indigenous cattle breeds were analyzed. One LD block was found in three cattle breeds. The statistical analyses indicated that AC genotype of Z4 locus was associated with the high body weight, body length and chest girth in Jiaxian cattle breed (P?AZGP1 gene were associated with growth traits, and may be used for marker-assisted selection and management in cattle breeding program. |
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