Atherosclerosis in early rheumatoid arthritis: very early endothelial activation and rapid progression of intima media thickness |
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Authors: | Anna S?dergren Kjell Karp Kurt Boman Catharina Eriksson Elisabet Lundstr?m Torgny Smedby Lisbet S?derlund Solbritt Rantap??-Dahlqvist Solveig W?llberg-Jonsson |
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Institution: | (1) Department of Public Health and Clinical Medicine/Rheumatology, University Hospital, 901 85 Ume?, Sweden;(2) Department of Surgical and Perioperative Sciences, University Hospital, 901 85 Ume?, Sweden;(3) Department of Medicine, Skellefte? Hospital, Lasarettsv?gen, 931 86, Skellefte?, Sweden;(4) Department of Clinical Immunology, University Hospital, 901 85 Ume?, Sweden;(5) Department of Rheumatology, ?stersund Hospital, Kyrkgatan, 831 83, ?stersund, Sweden;(6) Department of Rheumatology, Sunderby Hospital, 971 80 Lule?, Sweden |
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Abstract: | Introduction In this study we aimed to investigate whether there are indications of premature atherosclerosis, as measured by endothelial
dependent flow-mediated dilation (ED-FMD) and intima media thickness (IMT), in patients with very early RA, and to analyze
its relation to biomarkers of endothelial dysfunction, taking inflammation and traditional cardiovascular disease (CVD) risk
factors into account. |
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Keywords: | |
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