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ent-Abietane diterpenoids from Isodon rubescens var. rubescens |
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| Authors: | Huang Sheng-Xiong Pu Jian-Xin Xiao Wei-Lie Li Li-Mei Weng Zhi-Ying Zhou Yan Han Quan-Bin Peng Shu-Lin Ding Li-Sheng Lou Li-Guang Sun Han-Dong |
| Affiliation: | State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China. |
| Abstract: | ent-Abietane diterpenoids, hebeiabinins A-F (1-5), together with seven known diterpenoids were isolated from leaves of Isodon rubescens var. rubescens. The structures of 1-5 were established on the basis of spectroscopic analyses, including application of 2D NMR spectroscopic techniques. The diterpenoids isolated were evaluated for the cytotoxicity against A549, HT-29, and K562 tumor cells. Compound 5 was the most active with IC(50) value of 0.91 microM against A549 cells. |
| Keywords: | Isodon rubescens var. rubescens Labiatae ent-Abietane Hebeiabinin Diterpenoid Cytotoxicity |
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