Mechanisms for the formation of membranous nanostructures in cell-to-cell communication |
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| Authors: | Karin Schara Vid Janša Vid Šuštar Drago Dolinar Janez Ivan Pavlič Maruša Lokar Veronika Kralj-Iglič Peter Veranič Aleš Iglič |
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| Affiliation: | (1) Laboratory of Clinical Biophysics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia;(2) Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Ljubljana, Slovenia;(3) Department of Rheumatology, University Medical Centre Ljubljana, Ljubljana, Slovenia;(4) Laboratory of Physics, Faculty of Electrical Engineering, University of Ljubljana, Tržaška 25, 1000 Ljubljana, Slovenia; |
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| Abstract: | Cells interact by exchanging material and information. Two methods of cell-to-cell communication are by means of microvesicles
and by means of nanotubes. Both microvesicles and nanotubes derive from the cell membrane and are able to transport the contents
of the inner solution. In this review, we describe two physical mechanisms involved in the formation of microvesicles and
nanotubes: curvature-mediated lateral redistribution of membrane components with the formation of membrane nanodomains; and
plasmamediated attractive forces between membranes. These mechanisms are clinically relevant since they can be affected by
drugs. In particular, the underlying mechanism of heparin’s role as an anticoagulant and tumor suppressor is the suppression
of microvesicluation due to plasma-mediated attractive interaction between membranes. |
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