| O1/O139新型霍乱疫苗口服免疫动物后的自动免疫保护及被动保护试验研究 |
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| 引用本文： | 陈翠萍,宣俊文,王永谦,杨朝晖.O1/O139新型霍乱疫苗口服免疫动物后的自动免疫保护及被动保护试验研究[J].微生物学免疫学进展,2003,31(3):18-21. |
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| 作者姓名： | 陈翠萍 宣俊文 王永谦 杨朝晖 |
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| 作者单位： | 兰州生物制品研究所,兰州,730046 |
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| 摘 要： | O1／O139霍乱口服疫苗是一种新型疫苗。本文通过2种不同途径免疫动物，检测血清抗菌抗体和肠道分泌性IgA抗体以及保护力试验，并探讨了它们之间的关系。通过家兔肠袢试验和细胞四甲基偶氮唑盐(MTT)试验检测免疫后抗血清的被动保护作用。试验提示：在霍乱的保护性免疫应答中，除粘膜免疫可能占主导作用外，血清抗菌抗体也发挥了一定的作用。
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| 关 键 词： | 霍乱疫苗 保护性免疫 粘膜免疫 |
| 文章编号： | 1005-5673(2003)03-0018-04 |
| 修稿时间： | 2003年3月14日 |
Passive and active immno-protection tests with a new type of oral Cholera O1/O139 Vaccine |
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| CHEN Cui-ping,XUAN Jun-wen,WANG Yong-qian,et al..Passive and active immno-protection tests with a new type of oral Cholera O1/O139 Vaccine[J].Progress In Microbiology and Immunology,2003,31(3):18-21. |
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| Authors: | CHEN Cui-ping XUAN Jun-wen WANG Yong-qian |
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| Abstract: | Oral O1-O139 cholerae vaccine is a new vaccine.This paper reported that animals were immunized with two different route, the antibacterial antibody in serum and secretory antibody in intestine were tested as well as the protective experiment was performed The relationships between them were also discussed.Passive protection effects were tested by rabbit ligated intestinal loop experiment and MTT experiment.The results showed that mucosa immune might have important effect while the antibacterial antibody in serum also have a certain action. |
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| Keywords: | Cholerae vaccine Protective immune Mucosa immune |
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