Sonic Hedgehog基因及其在发育过程中的调控作用

Sonic Hedgehog(Shh)基因属于Hedgehog(Hh)基因家族,该家族最早在果蝇体内被发现,进化上呈高度保守状态。Sonic Hedgehog定位在7号染色体长臂远端(7q36),其通过细胞表面特殊受体Patched(Ptc)和Smoothened(Smo)被接收和传导,从而激活锌指蛋白C i/G li家族。Sonic Hedgehog基因作为重要的形态发生素,在胚胎发育、机体器官组织形成的过程中发挥了重要的作用,它的缺失或者失活会导致一系列严重的遗传疾病。其与体节、神经管、消化道、头面部、上下肢芽的发育以及肿瘤形成等有密切关系。本文主要就Sonic Hedgehog基因及其在发育中的调控作用作一综述。

The Regulation of Sonic Hedgehog Gene in the Development Process*

ABSTRACT:Sonic Hedgehog (Shh) gene belongs to the Hedgehog (Hh) gene family.It was found in fruit flies, and was highly conserved in the evolution. Sonic Hedgehog is positioned at the 7th to distal chromosome (7q36), via cell surface particular receptor Patched (Ptc) and Smoothened (Smo) is received and conduction, thereby activating the zinc finger protein C i / G Li family. Sonic Hedgehog gene as an important form occurs prime, played an important role in the process of embryonic development, the formation of organs and tissues of the body, its absence or inactivation will lead to a series of serious genetic diseases. Somite, neural tube, gastrointestinal, head and face, lower limb bud developm-ent and tumor formation are closely related. This review focuses on the the regulation of Sonic Hedgehog gene in the development process.