An estimate of polymorphism of ADH1B,ALDH2, and CYP2E1 alcohol biotransformation genes in Siberian indigenous and immigrant populations |
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Authors: | N V Solopekin |
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Institution: | 1.Faculty of Genetics,Kemerovo State University,Kemerovo,Russia |
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Abstract: | In the present article, the polymorphism of ADH1B, ALDH2, and CYP2E1 genes is studied in populations of Shors, Russians of
Siberia, and progenies of mixed Russian-Shor marriages. Reliable differences between groups according to the frequency of
ADH1B, ALDH2, and CYP2E1 genotypes and alleles are revealed. The article shows the high heterozygosis levels of the ADH1B
and ALDH2 genes. Gene distances prove that mongrels and Shors are very close to each other (d = 0.005) and Russians of Siberia are not similar to the Russians of the Central Russia (d = 0.046). |
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Keywords: | |
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