Impact of transduction towards the proliferation and migration as well as the transduction efficiency of human umbilical cord-derived late endothelial progenitor cells with nine recombinant adeno-associated virus serotypes期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Impact of transduction towards the proliferation and migration as well as the transduction efficiency of human umbilical cord-derived late endothelial progenitor cells with nine recombinant adeno-associated virus serotypes

Authors:	Zhaofei Wang Qiang Fu Jianguo Cao Xiyun Deng Yue Li Qiaofeng Wang Zhaofen Zheng

Institution:	1.Department of Cardiology of Hunan Provincial People’s Hospital,The First Affiliated Hospital of Hunan Normal University,Changsha,China;2.The Medical College of Hunan Normal University,Changsha,China;3.The Medical College of Nanhua University,Hengyang,China

Abstract:	Objectives To evaluate the transduction efficiency of human umbilical cord-derived, late endothelial progenitor cells late (HUCB-late EPCs) with nine recombinant adeno-associated virus (rAAV) serotypes and the ability of proliferation and migration of the cells after transduction. Results rAAV2 and rAAV6 showed a greater ability than other serotypes to transduce late EPCs (P < 0.05). After transduction, cell proliferation ability weakened (P < 0.05), but the ability of migration to stromal cell-derived factor (SDF-1) unchanged. Conclusion There is an advantage of choosing the optimal rAAV serotype as a gene vector to alter the biologic characteristics of late EPCs.

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