Overproduction of L-cysteine and L-cystine by expression of genes for feedback inhibition-insensitive serine acetyltransferase from Arabidopsis thaliana in Escherichia coli |
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Authors: | Hiroshi Takagi Naoki Awano Shin-ichiro Kobayashi Masaaki Noji Kazuki Saito Shigeru Nakamori |
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Institution: | Department of Bioscience, Fukui Prefectural University, 4-1-1 Kenjojima, Matsuoka-cho, Fukui, Japan. hiro@fpu.ac.jp |
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Abstract: | Two cDNAs encoding feedback inhibition-insensitive serine acetyltransferases of Arabidopsis thaliana were expressed in the chromosomal serine acetyltransferase-deficient and L-cysteine non-utilizing Escherichia coli strain JM39-8. The transformants produced 1600 to 1700 mg l(-1) of L-cysteine and L-cystine from glucose. The amount of these amino acids produced per cell was 30 to 60% higher than that of an E. coli strain carrying mutant serine acetyltransferase less sensitive to feedback inhibition. |
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Keywords: | L-Cysteine overproduction Feedback inhibition Serine acetyltransferase Arabidopsis thaliana |
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