Correlation between manganese-deficiency,loss of respiratory chain complex I activity and citric acid production in Aspergillus niger |
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Authors: | Jürgen Wallrath Michael Schmidt Hanns Weiss |
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Institution: | (1) Institut für Biochemie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, W-4000 Düsseldorf 1, Federal Republic of Germany |
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Abstract: | The correlation between manganese deficiency, loss of mitochondrial respiratory chain NADH: ubiquinone oxidoreductase (complex I) activity and citric acid overproduction in the Aspergillus niger strain B 60 was analysed. With increasing manganese-supplementation of the production medium the loss of complex I activity and the production of citric acid was reduced. Addition of manganese during growth stopped further loss of complex I activity and further increase of citric acid production. A possible causality between complex I deficiency and citric acid overproduction is discussed. |
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Keywords: | Aspergillus niger Citric acid production NADH: ubiquinone reductase Manganese |
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