Regulation of antiviral CD8+ T cells by inhibitory natural killer cell receptors |
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| Authors: | Byers Anthony M Kemball Christopher C Andrews Nicolas P Lukacher Aron E |
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| Affiliation: | Department of Pathology and Laboratory Medicine, Woodruff Memorial Research Building, Rm. 7307, Emory University School of Medicine, 1639 Pierce Drive, Atlanta, GA 30322, USA. |
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| Abstract: | Recent evidence indicates that CD8(+) T cells express natural killer cell receptors that constrain the range and magnitude of their activities. For virus-specific CD8(+) T cells, upregulation of these receptors serves to control infection, while concurrently minimizing bystander pathology. Dysregulated expression of these receptors, however, may foster the establishment of persistent virus infection. |
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